Neuroscience researchers identify new clue to Angelman syndrome

Department of Neuroscience stem cell researchers identify new clue to the neurological basis for Angelman syndrome:

Angelman syndrome
Short Circuit: Stem cells derived from people with Angelman syndrome do not develop mature electrical firing patterns.  Levine Lab

A new stem cell model of Angelman syndrome delivers evidence for three molecular mechanisms underlying the condition — and one potential treatment. Researchers presented the unpublished results today at the 2016 Society for Neuroscience annual meeting in San Diego.

The study found that the primary genetic cause of the syndrome, deletion of the UBE3A gene, short-circuits electrical activity in developing neurons. And faulty electrical activity may prevent the cells from forging and maintaining connections, or synapses, with neighboring neurons.

Read more about this new clue to the neurological basis for Angelman syndrome here.

John Wizeman, Ph.D. Candidate, Defends Public Thesis Defense

John WizemanJohn Wizeman recently defended his public thesis defense, entitled “The Role of Citrullination and the Type III Intermediate Filaments in Retinal gliosis” on August 19, 2016; major advisor Dr. Royce Mohan.

He will begin his postdoc at UConn Health in the department of Genetics & Genome Sciences with Dr. James Li.

On behalf of the Department of Neuroscience Program – we wish Dr. Wizeman much success!  🙂



Mandakini Singh, Ph.D. Candidate, Success at GSRD

Mandakini Singh, Ph.D. CandidateThe 33rd Annual Graduate Student Research Day (GSRD) took place on Thursday, June 9, 2016. This was a very special day for our graduate students at UConn Health. The day included student talks, a poster session and a keynote address by Dr. Deborah Hogan.

Several awards were given out, and we are pleased to announce and congratulate Mandakini Singh for 1st place in the poster presentations. Mandakini presented, “Mechanisms of Spontaneous Electrical Activity in the Developing Cerebral Cortex – Subplate Zone” and is doing her thesis research in the Antic Lab.